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Type II Anion Relay Chemistry: Exploiting Bifunctional Weinreb Amide Linchpins for the One-Pot Synthesis of Differentiated 1,3-Diketones, Pyrans, and Spiroketals

The design, synthesis, and validation of new highly effective bifunctional linchpins for type II anion relay chemistry (ARC) has been achieved. The mechanistically novel negative-charge migration that comprises the Brook rearrangement is now initiated by a stabilized tetrahedral intermediate, which...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Farrell, Mark, Melillo, Bruno, Smith, Amos B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4726982/
https://ncbi.nlm.nih.gov/pubmed/26586577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201509342
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