Alcohol Dehydrogenase Protects against Endoplasmic Reticulum Stress-Induced Myocardial Contractile Dysfunction via Attenuation of Oxidative Stress and Autophagy: Role of PTEN-Akt-mTOR Signaling

BACKGROUND: The endoplasmic reticulum (ER) plays an essential role in ensuring proper folding of the newly synthesized proteins. Aberrant ER homeostasis triggers ER stress and development of cardiovascular diseases. ADH is involved in catalyzing ethanol to acetaldehyde although its role in cardiovas...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Pang, Jiaojiao, Fuller, Nathan D., Hu, Nan, Barton, Linzi A., Henion, Jeremy M., Guo, Rui, Chen, Yuguo, Ren, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4726758/
https://ncbi.nlm.nih.gov/pubmed/26807981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0147322
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