Alcohol Dehydrogenase Protects against Endoplasmic Reticulum Stress-Induced Myocardial Contractile Dysfunction via Attenuation of Oxidative Stress and Autophagy: Role of PTEN-Akt-mTOR Signaling

BACKGROUND: The endoplasmic reticulum (ER) plays an essential role in ensuring proper folding of the newly synthesized proteins. Aberrant ER homeostasis triggers ER stress and development of cardiovascular diseases. ADH is involved in catalyzing ethanol to acetaldehyde although its role in cardiovas...

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Udgivet i:PLoS One
Main Authors: Pang, Jiaojiao, Fuller, Nathan D., Hu, Nan, Barton, Linzi A., Henion, Jeremy M., Guo, Rui, Chen, Yuguo, Ren, Jun
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4726758/
https://ncbi.nlm.nih.gov/pubmed/26807981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0147322
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