Tubastatin A, an HDAC6 inhibitor, alleviates stroke-induced brain infarction and functional deficits: potential roles of α-tubulin acetylation and FGF-21 up-regulation

Histone deacetylase (HDAC) 6 exists exclusively in cytoplasm and deacetylates cytoplasmic proteins such as α-tubulin. HDAC6 dysfunction is associated with several pathological conditions in the central nervous system. This study investigated the beneficial effects of tubastatin A (TubA), a novel spe...

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Publicado en:Sci Rep
Autores principales: Wang, Zhifei, Leng, Yan, Wang, Junyu, Liao, Hsiao-Mei, Bergman, Joel, Leeds, Peter, Kozikowski, Alan, Chuang, De-Maw
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4726180/
https://ncbi.nlm.nih.gov/pubmed/26790818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep19626
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