Structural Insights into the Quaternary Catalytic Mechanism of Hexameric Human Quinolinate Phosphoribosyltransferase, a Key Enzyme in de novo NAD Biosynthesis

Quinolinate phosphoribosyltransferase (QPRT) catalyses the production of nicotinic acid mononucleotide, a precursor of de novo biosynthesis of the ubiquitous coenzyme nicotinamide adenine dinucleotide. QPRT is also essential for maintaining the homeostasis of quinolinic acid in the brain, a possible...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Youn, Hyung-Seop, Gyun Kim, Tae, Kim, Mun-Kyoung, Bu Kang, Gil, Youn Kang, Jung, Lee, Jung-Gyu, Yop An, Jun, Ryoung Park, Kyoung, Lee, Youngjin, Jun Im, Young, Hyuck Lee, Jun, Hyun Eom, Soo
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4726147/
https://ncbi.nlm.nih.gov/pubmed/26805589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep19681
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