A CRISPR/Cas9 and Cre/Lox system-based express vaccine development strategy against re-emerging Pseudorabies virus

Virus evolves rapidly to escape vaccine-induced immunity, posing a desperate demand for efficient vaccine development biotechnologies. Here we present an express vaccine development strategy based on CRISPR/Cas9 and Cre/Lox system against re-emerging Pseudorabies virus, which caused the recent devas...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Liang, Xun, Sun, Leqiang, Yu, Teng, Pan, Yongfei, Wang, Dongdong, Hu, Xueying, Fu, Zhenfang, He, Qigai, Cao, Gang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4726036/
https://ncbi.nlm.nih.gov/pubmed/26777545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep19176
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