Depot injectable atorvastatin biodegradable in situ gel: development, optimization, in vitro, and in vivo evaluation

This study aimed to develop an optimized depot injectable atorvastatin (ATR) biodegradable in situ gel (ISG) system with minimum initial burst using a central composite design. The factors selected were poly (d, l-lactide-co-glycolide) (PLGA) concentration (X(1)), molecular weight of polyethylene gl...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Ahmed, Tarek A, Alharby, Yasser A, El-Helw, Abdel-Rahim M, Hosny, Khaled M, El-Say, Khalid M
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725642/
https://ncbi.nlm.nih.gov/pubmed/26855565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S98078
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