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Development and optimization of carvedilol orodispersible tablets: enhancement of pharmacokinetic parameters in rabbits
BACKGROUND: Carvedilol (CVD) is used for the treatment of essential hypertension, heart failure, and systolic dysfunction after myocardial infarction. Due to its lower aqueous solubility and extensive first-pass metabolism, the absolute bioavailability of CVD does not exceed 30%. To overcome these d...
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| Publicado no: | Drug Des Devel Ther |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Dove Medical Press
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4357615/ https://ncbi.nlm.nih.gov/pubmed/25834396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S80294 |
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