Development and optimization of carvedilol orodispersible tablets: enhancement of pharmacokinetic parameters in rabbits

BACKGROUND: Carvedilol (CVD) is used for the treatment of essential hypertension, heart failure, and systolic dysfunction after myocardial infarction. Due to its lower aqueous solubility and extensive first-pass metabolism, the absolute bioavailability of CVD does not exceed 30%. To overcome these d...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Drug Des Devel Ther
Autori principali: Aljimaee, Yazeed HM, El-Helw, Abdel-Rahim M, Ahmed, Osama AA, El-Say, Khalid M
Natura: Artigo
Lingua:Inglês
Pubblicazione: Dove Medical Press 2015
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4357615/
https://ncbi.nlm.nih.gov/pubmed/25834396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S80294
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi