Development and optimization of carvedilol orodispersible tablets: enhancement of pharmacokinetic parameters in rabbits

BACKGROUND: Carvedilol (CVD) is used for the treatment of essential hypertension, heart failure, and systolic dysfunction after myocardial infarction. Due to its lower aqueous solubility and extensive first-pass metabolism, the absolute bioavailability of CVD does not exceed 30%. To overcome these d...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Drug Des Devel Ther
Päätekijät: Aljimaee, Yazeed HM, El-Helw, Abdel-Rahim M, Ahmed, Osama AA, El-Say, Khalid M
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Dove Medical Press 2015
Aiheet:
Original Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4357615/
https://ncbi.nlm.nih.gov/pubmed/25834396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S80294
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