An Optimized Surfactant-Based PEG-PLCL In Situ Gel Formulation For Enhanced Activity Of Rosuvastatin In Poloxamer-Induced Hyperlipidemic Rats

BACKGROUND: Injectable in situ gel (ISG) systems suffer from high initial drug release that may result in toxic effects. OBJECTIVE: This work aimed to develop an injectable sustained release rosuvastatin (RSV) ISG formulation with minimum initial drug burst and improved hyperlipidemic efficacy. METH...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Ahmed, Tarek A, Mussari, Mohammed A, Abdel-Hady, Seham El-Sayed, El-Say, Khalid M
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2019
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6904902/
https://ncbi.nlm.nih.gov/pubmed/31839704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S224442
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