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The tobacco smoke component acrolein induces glucocorticoid resistant gene expression via inhibition of histone deacetylase
Chronic obstructive pulmonary disease (COPD) is the leading cause of cigarette smoke-related death worldwide. Acrolein, a crucial reactive electrophile found in cigarette smoke mimics many of the toxic effects of cigarette smoke-exposure in the lung. In macrophages, cigarette smoke is known to hinde...
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| Publicado en: | Toxicol Lett |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4725588/ https://ncbi.nlm.nih.gov/pubmed/26481333 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxlet.2015.10.009 |
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