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The Tobacco Smoke Component, Acrolein, Suppresses Innate Macrophage Responses by Direct Alkylation of c-Jun N-Terminal Kinase

The respiratory innate immune system is often compromised by tobacco smoke exposure, and previous studies have indicated that acrolein, a reactive electrophile in tobacco smoke, may contribute to the immunosuppressive effects of smoking. Exposure of mice to acrolein at concentrations similar to thos...

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Detalhes bibliográficos
Main Authors: Hristova, Milena, Spiess, Page C., Kasahara, David I., Randall, Matthew J., Deng, Bin, van der Vliet, Albert
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3262655/
https://ncbi.nlm.nih.gov/pubmed/21778411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2011-0134OC
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