Phosphorylation Increases Persistence Length and End-to-End Distance of a Segment of Tau Protein

Intrinsically disordered regions of proteins, which lack unique tertiary structure under physiological conditions, are enriched in phosphorylation sites and in significant local bias toward the polyproline II conformation. The overrepresented coincidence of this posttranslational regulatory signal a...

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Udgivet i:Biophys J
Main Authors: Chin, Alexander F., Toptygin, Dmitri, Elam, W. Austin, Schrank, Travis P., Hilser, Vincent J.
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2016
Fag:
Proteins
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725354/
https://ncbi.nlm.nih.gov/pubmed/26789759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.12.013
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