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Phosphorylation Increases Persistence Length and End-to-End Distance of a Segment of Tau Protein

Intrinsically disordered regions of proteins, which lack unique tertiary structure under physiological conditions, are enriched in phosphorylation sites and in significant local bias toward the polyproline II conformation. The overrepresented coincidence of this posttranslational regulatory signal a...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Chin, Alexander F., Toptygin, Dmitri, Elam, W. Austin, Schrank, Travis P., Hilser, Vincent J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725354/
https://ncbi.nlm.nih.gov/pubmed/26789759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.12.013
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