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Genes implicated in stem cell identity and temporal programme are directly targeted by Notch in neuroblast tumours

Notch signalling is involved in a multitude of developmental decisions and its aberrant activation is linked to many diseases, including cancers. One example is the neural stem cell tumours that arise from constitutive Notch activity in Drosophila neuroblasts. To investigate how hyperactivation of N...

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Bibliografske podrobnosti
izdano v:Development
Main Authors: Zacharioudaki, Evanthia, Housden, Benjamin E., Garinis, George, Stojnic, Robert, Delidakis, Christos, Bray, Sarah J.
Format: Artigo
Jezik:Inglês
Izdano: The Company of Biologists Ltd 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725341/
https://ncbi.nlm.nih.gov/pubmed/26657768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.126326
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