Mi-2/NuRD complex protects stem cell progeny from mitogenic Notch signaling

To progress towards differentiation, progeny of stem cells need to extinguish expression of stem-cell maintenance genes. Failures in such mechanisms can drive tumorigenesis. In Drosophila neural stem cell (NSC) lineages, excessive Notch signalling results in supernumerary NSCs causing hyperplasia. H...

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Bibliographic Details
Published in:eLife
Main Authors: Zacharioudaki, Evanthia, Falo Sanjuan, Julia, Bray, Sarah
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2019
Subjects:
Chromosomes and Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6379090/
https://ncbi.nlm.nih.gov/pubmed/30694174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.41637
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