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Genes implicated in stem cell identity and temporal programme are directly targeted by Notch in neuroblast tumours

Notch signalling is involved in a multitude of developmental decisions and its aberrant activation is linked to many diseases, including cancers. One example is the neural stem cell tumours that arise from constitutive Notch activity in Drosophila neuroblasts. To investigate how hyperactivation of N...

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Detalhes bibliográficos
Publicado no:Development
Main Authors: Zacharioudaki, Evanthia, Housden, Benjamin E., Garinis, George, Stojnic, Robert, Delidakis, Christos, Bray, Sarah J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725341/
https://ncbi.nlm.nih.gov/pubmed/26657768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.126326
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