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Dual function of Bmpr1a signaling in restricting preosteoblast proliferation and stimulating osteoblast activity in mouse

Exogenous bone morphogenetic proteins (Bmp) are well known to induce ectopic bone formation, but the physiological effect of Bmp signaling on normal bone is not completely understood. By deleting the receptor Bmpr1a in osteoblast lineage cells with Dmp1-Cre, we observed a dramatic increase in trabec...

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Bibliografski detalji
Izdano u:Development
Glavni autori: Lim, Joohyun, Shi, Yu, Karner, Courtney M., Lee, Seung-Yon, Lee, Wen-Chih, He, Guangxu, Long, Fanxin
Format: Artigo
Jezik:Inglês
Izdano: The Company of Biologists Ltd 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725340/
https://ncbi.nlm.nih.gov/pubmed/26657771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.126227
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