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Dual function of Bmpr1a signaling in restricting preosteoblast proliferation and stimulating osteoblast activity in mouse

Exogenous bone morphogenetic proteins (Bmp) are well known to induce ectopic bone formation, but the physiological effect of Bmp signaling on normal bone is not completely understood. By deleting the receptor Bmpr1a in osteoblast lineage cells with Dmp1-Cre, we observed a dramatic increase in trabec...

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Publicado en:Development
Autores principales: Lim, Joohyun, Shi, Yu, Karner, Courtney M., Lee, Seung-Yon, Lee, Wen-Chih, He, Guangxu, Long, Fanxin
Formato: Artigo
Lenguaje:Inglês
Publicado: The Company of Biologists Ltd 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725340/
https://ncbi.nlm.nih.gov/pubmed/26657771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.126227
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