Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma

Airway hyperresponsiveness and inflammation are fundamental hallmarks of allergic asthma that are accompanied by increases in certain polycations, such as eosinophil cationic protein. Levels of these cations in body fluids correlate with asthma severity. We show that polycations and elevated extrace...

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Wydane w:Sci Transl Med
Główni autorzy: Yarova, Polina L., Stewart, Alecia L., Sathish, Venkatachalem, Britt, Rodney D, Thompson, Michael A., Lowe, Alexander P. P., Freeman, Michelle, Aravamudan, Bharathi, Kita, Hirohito, Brennan, Sarah C., Schepelmann, Martin, Davies, Thomas, Yung, Sun, Cholisoh, Zakky, Kidd, Emma J., Ford, William R., Broadley, Kenneth J., Rietdorf, Katja, Chang, Wenhan, Khayat, Mohd E. Bin, Ward, Donald T., Corrigan, Christopher J., Ward, Jeremy P. T., Kemp, Paul J., Pabelick, Christina M., Prakash, Y. S., Riccardi, Daniela
Format: Artigo
Język:Inglês
Wydane: 2015
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Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725057/
https://ncbi.nlm.nih.gov/pubmed/25904744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaa0282
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