Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma

Airway hyperresponsiveness and inflammation are fundamental hallmarks of allergic asthma that are accompanied by increases in certain polycations, such as eosinophil cationic protein. Levels of these cations in body fluids correlate with asthma severity. We show that polycations and elevated extrace...

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Библиографические подробности
Опубликовано в: :Sci Transl Med
Главные авторы: Yarova, Polina L., Stewart, Alecia L., Sathish, Venkatachalem, Britt, Rodney D, Thompson, Michael A., Lowe, Alexander P. P., Freeman, Michelle, Aravamudan, Bharathi, Kita, Hirohito, Brennan, Sarah C., Schepelmann, Martin, Davies, Thomas, Yung, Sun, Cholisoh, Zakky, Kidd, Emma J., Ford, William R., Broadley, Kenneth J., Rietdorf, Katja, Chang, Wenhan, Khayat, Mohd E. Bin, Ward, Donald T., Corrigan, Christopher J., Ward, Jeremy P. T., Kemp, Paul J., Pabelick, Christina M., Prakash, Y. S., Riccardi, Daniela
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725057/
https://ncbi.nlm.nih.gov/pubmed/25904744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaa0282
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