Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma

Airway hyperresponsiveness and inflammation are fundamental hallmarks of allergic asthma that are accompanied by increases in certain polycations, such as eosinophil cationic protein. Levels of these cations in body fluids correlate with asthma severity. We show that polycations and elevated extrace...

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Publicado no:Sci Transl Med
Main Authors: Yarova, Polina L., Stewart, Alecia L., Sathish, Venkatachalem, Britt, Rodney D, Thompson, Michael A., Lowe, Alexander P. P., Freeman, Michelle, Aravamudan, Bharathi, Kita, Hirohito, Brennan, Sarah C., Schepelmann, Martin, Davies, Thomas, Yung, Sun, Cholisoh, Zakky, Kidd, Emma J., Ford, William R., Broadley, Kenneth J., Rietdorf, Katja, Chang, Wenhan, Khayat, Mohd E. Bin, Ward, Donald T., Corrigan, Christopher J., Ward, Jeremy P. T., Kemp, Paul J., Pabelick, Christina M., Prakash, Y. S., Riccardi, Daniela
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725057/
https://ncbi.nlm.nih.gov/pubmed/25904744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaa0282
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