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NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers
Nanog, a core pluripotency factor in the inner cell mass of blastocysts, is also expressed in unipotent primordial germ cells (PGC) in mice(1), where its precise role is yet unclear(2-4). We investigated this in an in vitro model, where naïve pluripotent embryonic stem cells (ESCs) cultured in bFGF/...
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| Izdano u: | Nature |
|---|---|
| Glavni autori: | , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2016
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4724940/ https://ncbi.nlm.nih.gov/pubmed/26751055 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature16480 |
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