NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers

Nanog, a core pluripotency factor in the inner cell mass of blastocysts, is also expressed in unipotent primordial germ cells (PGC) in mice(1), where its precise role is yet unclear(2-4). We investigated this in an in vitro model, where naïve pluripotent embryonic stem cells (ESCs) cultured in bFGF/...

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Foilsithe in:Nature
Main Authors: Murakami, Kazuhiro, Günesdogan, Ufuk, Zylicz, Jan J., Tang, Walfred W. C., Sengupta, Roopsha, Kobayashi, Toshihiro, Kim, Shinseog, Butler, Richard, Dietmann, Sabine, Surani, M. Azim
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4724940/
https://ncbi.nlm.nih.gov/pubmed/26751055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature16480
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