Pyruvate Dehydrogenase Activity Is Decreased in the Peripheral Blood Mononuclear Cells of Patients with Sepsis. A Prospective Observational Trial

Rationale: Rodent studies have shown that pyruvate dehydrogenase (PDH) levels are low in sepsis. This may cause cells to shift to anaerobic metabolism, resulting in increased lactate production. Alterations in PDH during sepsis have never been studied in humans. Objectives: The objective of this pil...

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Bibliografiske detaljer
Udgivet i:Ann Am Thorac Soc
Main Authors: Nuzzo, Erin, Berg, Katherine M., Andersen, Lars W., Balkema, Julia, Montissol, Sophia, Cocchi, Michael N., Liu, Xiaowen, Donnino, Michael W.
Format: Artigo
Sprog:Inglês
Udgivet: American Thoracic Society 2015
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4724894/
https://ncbi.nlm.nih.gov/pubmed/26356483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1513/AnnalsATS.201505-267BC
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