Pyruvate Dehydrogenase Activity Is Decreased in the Peripheral Blood Mononuclear Cells of Patients with Sepsis. A Prospective Observational Trial

Rationale: Rodent studies have shown that pyruvate dehydrogenase (PDH) levels are low in sepsis. This may cause cells to shift to anaerobic metabolism, resulting in increased lactate production. Alterations in PDH during sepsis have never been studied in humans. Objectives: The objective of this pil...

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Dettagli Bibliografici
Pubblicato in:Ann Am Thorac Soc
Autori principali: Nuzzo, Erin, Berg, Katherine M., Andersen, Lars W., Balkema, Julia, Montissol, Sophia, Cocchi, Michael N., Liu, Xiaowen, Donnino, Michael W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Thoracic Society 2015
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4724894/
https://ncbi.nlm.nih.gov/pubmed/26356483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1513/AnnalsATS.201505-267BC
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