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Sarcoplasmic Reticulum Structure and Functional Properties that Promote Long-Lasting Calcium Sparks

Calcium (Ca) sparks are the fundamental sarcoplasmic reticulum (SR) Ca release events in cardiac myocytes, and they have a typical duration of 20–40 ms. However, when a fraction of ryanodine receptors (RyRs) are blocked by tetracaine or ruthenium red, Ca sparks lasting hundreds of milliseconds have...

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Publicat a:Biophys J
Autors principals: Sato, Daisuke, Shannon, Thomas R., Bers, Donald M.
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4724649/
https://ncbi.nlm.nih.gov/pubmed/26789761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.12.009
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