Targeted mutagenesis of DNA using triple helix-forming oligonucleotides linked to psoralen.

Oligonucleotides can bind as third strands of DNA in a sequence-specific manner in the major groove in homopurine/homopyrimidine stretches in duplex DNA. Here we use a 10-base triplex-forming oligonucleotide linked to a psoralen derivative at its 5' end to achieve site-specific, targeted mutagenesis...

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Bibliografski detalji

Izdano u:	Proc Natl Acad Sci U S A
Glavni autori:	Havre, P A, Gunther, E J, Gasparro, F P, Glazer, P M
Format:	Artigo
Jezik:	Inglês
Izdano:	National Academy of Sciences 1993
Teme:	Research Article
Online pristup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47246/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8356097/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.16.7879
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