Identification of genotoxic compounds using isogenic DNA repair deficient DT40 cell lines on a quantitative high throughput screening platform

DNA repair pathways play a critical role in maintaining cellular homeostasis by repairing DNA damage induced by endogenous processes and xenobiotics, including environmental chemicals. Induction of DNA damage may lead to genomic instability, disruption of cellular homeostasis and potentially tumours...

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Veröffentlicht in:Mutagenesis
Hauptverfasser: Nishihara, Kana, Huang, Ruili, Zhao, Jinghua, Shahane, Sampada A., Witt, Kristine L., Smith-Roe, Stephanie L., Tice, Raymond R., Takeda, Shunichi, Xia, Menghang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4723671/
https://ncbi.nlm.nih.gov/pubmed/26243743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/mutage/gev055
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