Application of a cocktail approach to screen cytochrome P450 BM3 libraries for metabolic activity and diversity

In the present study, the validity of using a cocktail screening method in combination with a chemometrical data mining approach to evaluate metabolic activity and diversity of drug-metabolizing bacterial Cytochrome P450 (CYP) BM3 mutants was investigated. In addition, the concept of utilizing an in...

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Detalhes bibliográficos
Publicado no:Anal Bioanal Chem
Main Authors: Reinen, Jelle, Postma, Geert, Tump, Cornelis, Bloemberg, Tom, Engel, Jasper, Vermeulen, Nico P. E., Commandeur, Jan N. M., Honing, Maarten
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4723632/
https://ncbi.nlm.nih.gov/pubmed/26753974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00216-015-9241-x
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