Regulation of VEGF by mevalonate pathway inhibition in breast cancer

Aminobisphosphonates are used for the treatment of benign and malignant bone disorders. As inhibitors of the mevalonate pathway they exert direct anti-tumor effects in vitro and in preclinical models of bone metastases. Bisphosphonates are thought to have an anti-angiogenic activity as decreased lev...

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Detalhes bibliográficos
Publicado no:J Bone Oncol
Main Authors: Rachner, Tilman D., Göbel, Andy, Junker, Maria, Hötzel, Josefa, Benad-Mehner, Peggy, Hadji, Peyman, Hofbauer, Lorenz C.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4723384/
https://ncbi.nlm.nih.gov/pubmed/26909280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbo.2013.05.003
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