Dickkopf-1 is regulated by the mevalonate pathway in breast cancer

INTRODUCTION: Amino-bisphosphonates and statins inhibit the mevalonate pathway, and may exert anti-tumor effects. The Wnt inhibitor dickkopf-1 (DKK-1) promotes osteolytic bone lesions by inhibiting osteoblast functions and has been implicated as an adverse marker in multiple cancers. We assessed the...

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Main Authors: Rachner, Tilman D, Göbel, Andy, Thiele, Stefanie, Rauner, Martina, Benad-Mehner, Peggy, Hadji, Peyman, Bauer, Thomas, Muders, Michael H, Baretton, Gustavo B, Jakob, Franz, Ebert, Regina, Bornhäuser, Martin, Schem, Christian, Hofbauer, Lorenz C
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979025/
https://ncbi.nlm.nih.gov/pubmed/24528599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3616
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