Targeting syndecan-1 in breast cancer inhibits osteoclast functions through up-regulation of osteoprotegerin

BACKGROUND: Breast cancer often metastasizes into bone and leads to osteolytic lesions. The underlying mechanisms, however, are complex and not fully understood. Syndecan-1 is a proteoglycan that has various functions relevant for tumor progression including cell–cell communication and cell–matrix i...

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Detalhes bibliográficos
Publicado no:J Bone Oncol
Main Authors: Benad-Mehner, Peggy, Thiele, Stefanie, Rachner, Tilman D., Göbel, Andy, Rauner, Martina, Hofbauer, Lorenz C.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4723417/
https://ncbi.nlm.nih.gov/pubmed/26909290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbo.2013.11.001
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