Improved Muscle Function in Duchenne Muscular Dystrophy through L-Arginine and Metformin: An Investigator-Initiated, Open-Label, Single-Center, Proof-Of-Concept-Study

Altered neuronal nitric oxide synthase function in Duchenne muscular dystrophy leads to impaired mitochondrial function which is thought to be one cause of muscle damage in this disease. The study tested if increased intramuscular nitric oxide concentration can improve mitochondrial energy metabolis...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Hafner, Patricia, Bonati, Ulrike, Erne, Beat, Schmid, Maurice, Rubino, Daniela, Pohlman, Urs, Peters, Thomas, Rutz, Erich, Frank, Stephan, Neuhaus, Cornelia, Deuster, Stefanie, Gloor, Monika, Bieri, Oliver, Fischmann, Arne, Sinnreich, Michael, Gueven, Nuri, Fischer, Dirk
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4723144/
https://ncbi.nlm.nih.gov/pubmed/26799743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0147634
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