Improved Muscle Function in Duchenne Muscular Dystrophy through L-Arginine and Metformin: An Investigator-Initiated, Open-Label, Single-Center, Proof-Of-Concept-Study

Altered neuronal nitric oxide synthase function in Duchenne muscular dystrophy leads to impaired mitochondrial function which is thought to be one cause of muscle damage in this disease. The study tested if increased intramuscular nitric oxide concentration can improve mitochondrial energy metabolis...

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Publicat a:PLoS One
Autors principals: Hafner, Patricia, Bonati, Ulrike, Erne, Beat, Schmid, Maurice, Rubino, Daniela, Pohlman, Urs, Peters, Thomas, Rutz, Erich, Frank, Stephan, Neuhaus, Cornelia, Deuster, Stefanie, Gloor, Monika, Bieri, Oliver, Fischmann, Arne, Sinnreich, Michael, Gueven, Nuri, Fischer, Dirk
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4723144/
https://ncbi.nlm.nih.gov/pubmed/26799743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0147634
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