Effect of Combination l-Citrulline and Metformin Treatment on Motor Function in Patients With Duchenne Muscular Dystrophy: A Randomized Clinical Trial

IMPORTANCE: Nitric oxide precursors, such as the amino acid l-arginine and the biguanide antidiabetic drug metformin, have been associated with metabolism and muscle function in patients with Duchenne muscular dystrophy (DMD). The treatment of DMD remains an unmet medical need. OBJECTIVE: To evaluat...

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Detalhes bibliográficos
Publicado no:JAMA Netw Open
Main Authors: Hafner, Patricia, Bonati, Ulrike, Klein, Andrea, Rubino, Daniela, Gocheva, Vanya, Schmidt, Simone, Schroeder, Jonas, Bernert, Günther, Laugel, Vincent, Steinlin, Maja, Capone, Andrea, Gloor, Monika, Bieri, Oliver, Hemkens, Lars G., Speich, Benjamin, Zumbrunn, Thomas, Gueven, Nuri, Fischer, Dirk
Formato: Artigo
Idioma:Inglês
Publicado em: American Medical Association 2019
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6824222/
https://ncbi.nlm.nih.gov/pubmed/31664444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamanetworkopen.2019.14171
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