Effect of Combination l-Citrulline and Metformin Treatment on Motor Function in Patients With Duchenne Muscular Dystrophy: A Randomized Clinical Trial

IMPORTANCE: Nitric oxide precursors, such as the amino acid l-arginine and the biguanide antidiabetic drug metformin, have been associated with metabolism and muscle function in patients with Duchenne muscular dystrophy (DMD). The treatment of DMD remains an unmet medical need. OBJECTIVE: To evaluat...

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Publicado en:JAMA Netw Open
Autores principales: Hafner, Patricia, Bonati, Ulrike, Klein, Andrea, Rubino, Daniela, Gocheva, Vanya, Schmidt, Simone, Schroeder, Jonas, Bernert, Günther, Laugel, Vincent, Steinlin, Maja, Capone, Andrea, Gloor, Monika, Bieri, Oliver, Hemkens, Lars G., Speich, Benjamin, Zumbrunn, Thomas, Gueven, Nuri, Fischer, Dirk
Formato: Artigo
Lenguaje:Inglês
Publicado: American Medical Association 2019
Materias:
Original Investigation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6824222/
https://ncbi.nlm.nih.gov/pubmed/31664444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamanetworkopen.2019.14171
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