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PDGF-DEPENDENT β-CATENIN ACTIVATION IS ASSOCIATED WITH ABNORMAL PULMONARY ARTERY SMOOTH MUSCLE CELL PROLIFERATION IN PULMONARY ARTERIAL HYPERTENSION

Pulmonary arterial hypertension (PAH) is characterized by excessive pulmonary arterial smooth muscle cells (PASMCs) growth, partially in response to PDGF-BB but whether this is dependent on β-catenin (βC) activation is unclear. Compared to healthy cells, PAH PASMCs demonstrate higher levels of proli...

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Detalhes bibliográficos
Publicado no:FEBS Lett
Main Authors: Takahashi, Jack, Orcholski, Mark, Yuan, Ke, de Jesus Perez, Vinicio
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4722963/
https://ncbi.nlm.nih.gov/pubmed/26787464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.12038
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