Rapamycin reverses pulmonary artery smooth muscle cell proliferation in pulmonary hypertension

Pulmonary-artery smooth-muscle-cell (PA-SMC) proliferation in pulmonary hypertension (PH) may be linked to dysregulated mammalian target of rapamycin (mTOR) signaling. The mTOR pathway involves two independent complexes, mTORC1 and mTORC2, which phosphorylate S6K and Akt, respectively, and differ in...

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Publicado en:Am J Respir Cell Mol Biol
Autores principales: Houssaini, Amal, Abid, Shariq, Mouraret, Nathalie, Wan, Feng, Rideau, Dominique, Saker, Mirna, Marcos, Elisabeth, Tissot, Claire-Marie, Dubois-Randé, Jean-Luc, Amsellem, Valérie, Adnot, Serge
Formato: Artigo
Lenguaje:Inglês
Publicado: American Thoracic Society 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4901163/
https://ncbi.nlm.nih.gov/pubmed/23470622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2012-0429OC
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