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Rapamycin reverses pulmonary artery smooth muscle cell proliferation in pulmonary hypertension
Pulmonary-artery smooth-muscle-cell (PA-SMC) proliferation in pulmonary hypertension (PH) may be linked to dysregulated mammalian target of rapamycin (mTOR) signaling. The mTOR pathway involves two independent complexes, mTORC1 and mTORC2, which phosphorylate S6K and Akt, respectively, and differ in...
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| Publicado no: | Am J Respir Cell Mol Biol |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Thoracic Society
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4901163/ https://ncbi.nlm.nih.gov/pubmed/23470622 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2012-0429OC |
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