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Pulmonary artery smooth muscle cell senescence is a pathogenic mechanism for pulmonary hypertension in chronic lung disease

RATIONALE: Senescence of pulmonary artery-smooth muscle cells (PA-SMCs) caused by telomere shortening or oxidative stress may contribute to pulmonary hypertension (PH) associated with chronic lung diseases. OBJECTIVE: To investigate whether cell senescence contributes to pulmonary vessel remodeling...

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Main Authors: Noureddine, Hibo, Gary-Bobo, Guillaume, Alifano, Marco, Marcos, Elisabeth, Saker, Mirna, Vienney, Nora, Amsellem, Valérie, Maitre, Bernard, Chaouat, Ari, Chouaid, Christos, Dubois-Rande, Jean-Luc, Damotte, Diane, Adnot, Serge
Format: Artigo
Sprog:Inglês
Udgivet: Lippincott Williams & Wilkins 2011
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375237/
https://ncbi.nlm.nih.gov/pubmed/21719760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.111.241299
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