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Allosteric stabilization of the amyloid-β peptide hairpin by the fluctuating N-terminal

Immobilized ions modulate nearby hydrophobic interactions and influence molecular recognition and self-assembly. We simulated disulfide bond-locked double mutants (L17C/L34C) and observed allosteric modulation of the peptide's intra-molecular interactions by the N-terminal tail. We revealed tha...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Chem Commun (Camb)
Main Authors: Xu, Liang, Nussinov, Ruth, Ma, Buyong
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4720562/
https://ncbi.nlm.nih.gov/pubmed/26666686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5cc08107f
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