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The Stability of Monomeric Intermediates Controls Amyloid Formation: Aβ25–35 and its N27Q Mutant
The structure and stabilities of the intermediates affect protein folding as well as misfolding and amyloid formation. By applying Kramer's theory of barrier crossing and a Morse-function-like energy landscape, we show that intermediates with medium stability dramatically increase the rate of a...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Biophysical Society
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1440722/ https://ncbi.nlm.nih.gov/pubmed/16500972 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.075309 |
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