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An Effective Bifunctional Aldehyde Linchpin for Type II Anion Relay Chemistry: Development and Application to the Synthesis of a C16–C29 Fragment of Rhizopodin

[Image: see text] The design, synthesis, and validation of a new bifunctional aldehyde linchpin for Type II anion relay chemistry have been achieved. For this linchpin, the initial nucleophilic addition proceeds under Felkin–Anh control to generate the syn-alkoxide, which undergoes a 1,4-Brook rearr...

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Bibliografiske detaljer
Udgivet i:Org Lett
Main Authors: Melillo, Bruno, Chen, Ming Z., Forestieri, Roberto, Smith, Amos B.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2015
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4720133/
https://ncbi.nlm.nih.gov/pubmed/26641664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.5b03235
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