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RNA Replication and Membrane Modification Require the Same Functions of Alphavirus Nonstructural Proteins

The alphaviruses induce membrane invaginations known as spherules as their RNA replication sites. Here, we show that inactivation of any function (polymerase, helicase, protease, or membrane association) essential for RNA synthesis also prevents the generation of spherule structures in a Semliki For...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Kallio, Katri, Hellström, Kirsi, Jokitalo, Eija, Ahola, Tero
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4719637/
https://ncbi.nlm.nih.gov/pubmed/26581991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02484-15
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