RNA Replication and Membrane Modification Require the Same Functions of Alphavirus Nonstructural Proteins

The alphaviruses induce membrane invaginations known as spherules as their RNA replication sites. Here, we show that inactivation of any function (polymerase, helicase, protease, or membrane association) essential for RNA synthesis also prevents the generation of spherule structures in a Semliki For...

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Bibliografische gegevens
Gepubliceerd in:J Virol
Hoofdauteurs: Kallio, Katri, Hellström, Kirsi, Jokitalo, Eija, Ahola, Tero
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2016
Onderwerpen:
Genome Replication and Regulation of Viral Gene Expression
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4719637/
https://ncbi.nlm.nih.gov/pubmed/26581991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02484-15
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