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RNA Replication and Membrane Modification Require the Same Functions of Alphavirus Nonstructural Proteins
The alphaviruses induce membrane invaginations known as spherules as their RNA replication sites. Here, we show that inactivation of any function (polymerase, helicase, protease, or membrane association) essential for RNA synthesis also prevents the generation of spherule structures in a Semliki For...
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| 出版年: | J Virol |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Microbiology
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4719637/ https://ncbi.nlm.nih.gov/pubmed/26581991 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02484-15 |
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