RNA Replication and Membrane Modification Require the Same Functions of Alphavirus Nonstructural Proteins

The alphaviruses induce membrane invaginations known as spherules as their RNA replication sites. Here, we show that inactivation of any function (polymerase, helicase, protease, or membrane association) essential for RNA synthesis also prevents the generation of spherule structures in a Semliki For...

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Библиографические подробности
Опубликовано в: :J Virol
Главные авторы: Kallio, Katri, Hellström, Kirsi, Jokitalo, Eija, Ahola, Tero
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2016
Предметы:
Genome Replication and Regulation of Viral Gene Expression
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4719637/
https://ncbi.nlm.nih.gov/pubmed/26581991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02484-15
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