Machupo Virus Expressing GPC of the Candid#1 Vaccine Strain of Junin Virus Is Highly Attenuated and Immunogenic

Machupo virus (MACV) is the causative agent of Bolivian hemorrhagic fever. Our previous study demonstrated that a MACV strain with a single amino acid substitution (F438I) in the transmembrane domain of glycoprotein is attenuated but genetically unstable in mice. MACV is closely related to Junin vir...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Koma, Takaaki, Patterson, Michael, Huang, Cheng, Seregin, Alexey V., Maharaj, Payal D., Miller, Milagros, Smith, Jeanon N., Walker, Aida G., Hallam, Steven, Paessler, Slobodan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2016
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4719595/
https://ncbi.nlm.nih.gov/pubmed/26581982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02615-15
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