Population-Level Immune-Mediated Adaptation in HIV-1 Polymerase during the North American Epidemic

Human leukocyte antigen (HLA) class I-associated polymorphisms in HIV-1 that persist upon transmission to HLA-mismatched hosts may spread in the population as the epidemic progresses. Transmission of HIV-1 sequences containing such adaptations may undermine cellular immune responses to the incoming...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Kinloch, Natalie N., MacMillan, Daniel R., Le, Anh Q., Cotton, Laura A., Bangsberg, David R., Buchbinder, Susan, Carrington, Mary, Fuchs, Jonathan, Harrigan, P. Richard, Koblin, Beryl, Kushel, Margot, Markowitz, Martin, Mayer, Kenneth, Milloy, M. J., Schechter, Martin T., Wagner, Theresa, Walker, Bruce D., Carlson, Jonathan M., Poon, Art F. Y., Brumme, Zabrina L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Genetic Diversity and Evolution
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4719594/
https://ncbi.nlm.nih.gov/pubmed/26559841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02353-15
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