Genotypic and Functional Impact of HIV-1 Adaptation to Its Host Population during the North American Epidemic

HLA-restricted immune escape mutations that persist following HIV transmission could gradually spread through the viral population, thereby compromising host antiviral immunity as the epidemic progresses. To assess the extent and phenotypic impact of this phenomenon in an immunogenetically diverse p...

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Detalhes bibliográficos
Main Authors: Cotton, Laura A., Kuang, Xiaomei T., Le, Anh Q., Carlson, Jonathan M., Chan, Benjamin, Chopera, Denis R., Brumme, Chanson J., Markle, Tristan J., Martin, Eric, Shahid, Aniqa, Anmole, Gursev, Mwimanzi, Philip, Nassab, Pauline, Penney, Kali A., Rahman, Manal A., Milloy, M.-J., Schechter, Martin T., Markowitz, Martin, Carrington, Mary, Walker, Bruce D., Wagner, Theresa, Buchbinder, Susan, Fuchs, Jonathan, Koblin, Beryl, Mayer, Kenneth H., Harrigan, P. Richard, Brockman, Mark A., Poon, Art F. Y., Brumme, Zabrina L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3998893/
https://ncbi.nlm.nih.gov/pubmed/24762668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004295
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