MMP-9 facilitates selective proteolysis of the histone H3 tail at genes necessary for proficient osteoclastogenesis

Although limited proteolysis of the histone H3 N-terminal tail (H3NT) is frequently observed during mammalian differentiation, the specific genomic sites targeted for H3NT proteolysis and the functional significance of H3NT cleavage remain largely unknown. Here we report the first method to identify...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Genes Dev
Asıl Yazarlar: Kim, Kyunghwan, Punj, Vasu, Kim, Jin-Man, Lee, Sunyoung, Ulmer, Tobias S., Lu, Wange, Rice, Judd C., An, Woojin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cold Spring Harbor Laboratory Press 2016
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4719310/
https://ncbi.nlm.nih.gov/pubmed/26744418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.268714.115
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