H3K27me1 is essential for MMP-9-dependent H3N-terminal tail proteolysis during osteoclastogenesis

BACKGROUND: MMP-9 plays a direct role in the activation of pro-osteoclastogenic genes by cleaving histone H3N-terminal tail (H3NT) and altering chromatin architecture. Although H3 acetylation at K18 has been shown to stimulate MMP-9 enzymatic activity toward H3NT, nothing is known about the influenc...

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Dades bibliogràfiques
Publicat a:Epigenetics Chromatin
Autors principals: Kim, Kyunghwan, Shin, Yonghwan, Kim, Jinman, Ulmer, Tobias S., An, Woojin
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2018
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5971420/
https://ncbi.nlm.nih.gov/pubmed/29807539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-018-0193-1
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